Nucleotide-Protein Sequence Discrepancies in Toxoplasma gondii DHFR-TS: Database Annotation Issues and Phylogenetic Implications

This study investigates the evolutionary dynamics of dihydrofolate reductase-thymidylate synthase (DHFR-TS), a critical enzyme targeted by antifolate drugs in Toxoplasma gondii treatment. Through comprehensive phylogenetic analysis of 15 T. gondii strains, the research reveals significant discrepancies between genomic predictions and protein sequence annotations in public databases.

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2025-08-13
DOI
https://doi.org/10.5281/zenodo.16849353
Primary Topic
Botanical Studies and Applications
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Nucleotide-Protein Sequence Discrepancies in Toxoplasma gondii DHFR-TS: Database Annotation Issues and Phylogenetic Implications

Zenodo (CERN European Organization for Nuclear Research)
Botanical Studies and Applications
article

Nucleotide-Protein Sequence Discrepancies in Toxoplasma gondii DHFR-TS: Database Annotation Issues and Phylogenetic Implications

article en

Abstract

This study investigates the evolutionary dynamics of dihydrofolate reductase-thymidylate synthase (DHFR-TS), a critical enzyme targeted by antifolate drugs in Toxoplasma gondii treatment. Through comprehensive phylogenetic analysis of 15 T. gondii strains, the research reveals significant discrepancies between genomic predictions and protein sequence annotations in public databases.

Zenodo (CERN European Organization for Nuclear Research)
Openalex Percentile: Top 66%
Botanical Studies and Applications
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Nucleotide-Protein Sequence Discrepancies in Toxoplasma gondii DHFR-TS: Database Annotation Issues and Phylogenetic Implications · Zenodo (CERN European Organization for Nuclear Research) (2025) | TGRS Research Map | TGRS