Longévité OS : Compendium libre des biomarqueurs du vieillissement et des protocoles d'intervention open source

Abstract EN This document, produced with the assistance of ChatGPT o3 and ChatGPT 5 Thinking, is released under the Apache 2.0 licence. It is a voluntary defensive publication (prior art) and therefore enters the prior art upon release under the applicable patent statutes EPC Art. 54(2) (European Patent Convention), French IPC Art. L 611-11 (French Intellectual Property Code), 35 U.S.C. §102(a) (United States Patent Act), Chinese Patent Law Art. 22(5) (中华人民共和国专利法), and Japanese Patent Act Art. 29(1) (特許法). We disclose 77 enabling embodiments spanning assays/kits (telomeres, DNAm clocks, glycan-age, proteome, microbiome, metabolome, cfDNA-CHIP, mtDNA, 8-oxo-Gsn, NAD⁺), devices/sensors (AGE autofluorescence, VOP/PPG, continuous/interstitial NAD), AI/analytics (composite age, brain-age MRI, multimodal transformer, federated/DP, MLOps/QC), closed-loop protocols (senolytics, NAD scheduling, mTOR pre-vaccination, TRIIM-like, hormesis), delivery (microneedles, exosomes), imaging (MRI/MRS), and compliance/operations (FHIR consent, ATEX enclosures, logistics, calibration-as-a-service). Each proposal includes SOP-level parameters, IPC/CPC classifications, and timestamp proof (RFC 3161 / FreeTSA). Abstract FR Ce document, produit avec l’assistance de ChatGPT o3 et ChatGPT 5 Thinking, est diffusé sous licence Apache 2.0. Il constitue une publication défensive volontaire (prior art) et entre donc dans l’état de la technique dès sa mise en ligne au regard des lois applicables : EPC Art. 54(2) (Convention sur le brevet européen), French IPC Art. L 611-11 (Code de la propriété intellectuelle), 35 U.S.C. §102(a) (United States Patent Act), Chinese Patent Law Art. 22(5) (中华人民共和国专利法) et Japanese Patent Act Art. 29(1) (特許法). Nous divulguons 77 réalisations “enabling” couvrant essais/kits (télomères, horloges DNAm, glycan-age, protéome, microbiome, métabolome, cfDNA-CHIP, ADNmt, 8-oxo-Gsn, NAD⁺), dispositifs/capteurs (AGE cutané, VOP/PPG, NAD continu), IA/analytique (âge composite, brain-age IRM, transformer multimodal, fédéré/DP, MLOps/QC), protocoles en boucle fermée (sénolytiques, planification NAD, mTOR pré-vaccination, TRIIM-like, hormèse), délivrance (microneedles, exosomes), imagerie (IRM/MRS) et opérations/conformité (consentement FHIR, boîtiers ATEX, logistique, calibration-as-a-service). Chaque proposition inclut des paramètres de niveau SOP, des classes IPC/CPC et une preuve d’horodatage (RFC 3161 / FreeTSA). Timestamp : 2025-08-08T18:41:00ZSHA-256 : d23149bb7f0403edb1a1385ba16328c7e961d47848edd205893ba02dcf2911ce Innovations & Classifications (IPC ; CPC) : 1 — Kit qPCR télomères standardisé ; IPC C12Q 1/68 ; CPC C12Q 1/68862 — Horloge DNAm low-cost + pipeline ; IPC C12Q 1/68 ; CPC G16H 10/603 — Horloge fédérée (privacy) ; IPC G16H 50/20 ; CPC G06N 20/104 — p16INK4a T-cells RT-qPCR kit ; IPC C12Q 1/68 ; CPC G01N 33/5695 — Panel SASP sanguin multiplex ; IPC G01N 33/68 ; CPC G16H 10/606 — Âge protéomique 12-prot ; IPC G01N 33/53 ; CPC G16H 10/607 — GlycanAge sur DBS ; IPC G01N 33/68 ; CPC G01N 33/688 — Lecteur d’AGEs bi-spectral ; IPC A61B 5/145 ; CPC A61B 5/14559 — VOP PPG cuffless ; IPC A61B 5/00 ; CPC A61B 5/10310 — VO₂max smartphone ; IPC A61B 5/00 ; CPC G16H 50/2011 — Grip+gait IMU frailty ; IPC A61B 5/11 ; CPC A61B 5/11712 — Proxy NAD⁺ combiné ; IPC G01N 33/92 ; CPC G16H 10/6013 — Chrono-stack NAD (AM/PM) ; IPC A61K 31/00 ; CPC A61P 43/0014 — Sénolytique pulsé sécurisé ; IPC A61K 36/00 ; CPC A61P 43/0015 — Patch micro-aiguilles sénolyt. ; IPC A61M 37/00 ; CPC A61M 37/006616 — Cycle autophagie contrôlé ; IPC A61K 31/00 ; CPC A61P 43/0017 — “Mito-Cocktail” personnalisé ; IPC A61K 31/00 ; CPC A61P 21/0018 — Froid+exercice BAT tracking ; IPC A61H 15/00 ; CPC A61B 5/14519 — Régénération thymique guidée ; IPC A61K 38/00 ; CPC G16H 40/6320 — Échange plasmatique anti-âge ; IPC A61M 1/36 ; CPC A61M 1/3621 — FMT + prébiotiques “rejuv” ; IPC A61K 35/742 ; CPC A61P 1/0022 — Score âge composite (BACs) ; IPC G16H 50/20 ; CPC G06N 20/0023 — Logistique & stabilisation DBS ; IPC G01N 1/28 ; CPC B65D 81/3624 — MLOps âge biologique ; IPC G16H 50/20 ; CPC G06F 11/3625 — Protocole peau objectif ; IPC A61Q 19/00 ; CPC A61B 5/14526 — Assistant anti-AGEs cuisine ; IPC G16H 40/20 ; CPC G06N 20/0027 — Segmentation IRM thymus ; IPC A61B 5/055 ; CPC G06N 20/0028 — Biomarqueurs digitaux âge ; IPC G16H 50/20 ; CPC G06N 20/0029 — Clip AGE smartphone ; IPC G01N 21/64 ; CPC A61B 5/145530 — Boucle RL NAD personnalisée ; IPC G16H 20/10 ; CPC A61P 43/0031 — Puce piqûre-doigt autophagie ; IPC B01L 3/00 ; CPC C12Q 1/68832 — Lab-on-chip respirométrie ; IPC G01N 33/68 ; CPC B01L 3/502733 — Coque PWV+Grip ; IPC A61B 5/11 ; CPC A61B 5/14534 — Hematology Age Index ; IPC G16H 40/20 ; CPC G06N 20/0035 — Triage inflammaging ; IPC G01N 33/68 ; CPC G16H 40/2036 — Horloge protéomique aptamer ; IPC G01N 33/68 ; CPC G16H 40/2037 — Transcriptomic Age Lite ; IPC C12Q 1/68 ; CPC G06N 20/0038 — Microbiome Age Kit ; IPC C12Q 1/6895 ; CPC G16H 40/2039 — CHIP cfDNA monitor ; IPC C12Q 1/6883 ; CPC G16H 40/2040 — mtDNA Copy Chip ; IPC C12Q 1/68 ; CPC G01N 33/6841 — Patch circadien duo ; IPC A61B 5/00 ; CPC G01N 33/6842 — Hormetic Trio Optimizer ; IPC G16H 40/20 ; CPC A61H 33/0043 — Coach GlycanAge ; IPC G16H 40/20 ; CPC G01N 33/6844 — Thérapie nano-inhibiteur CD38 ; IPC A61K 31/708 ; CPC A61K 31/708845 — CAR-T anti-uPAR sénolytiques ; IPC C12N 15/90 ; CPC A61K 35/1746 — Reboot AAV-OSKM transitoire ; IPC C12N 15/90 ; CPC C12N 15/902347 — Dashboard âge multi-omique IA ; IPC G16H 50/20 ; CPC G16H 50/7048 — Patch NAD portable ; IPC G01N 27/327 ; CPC G01N 27/41749 — Home epigenetic chip ; IPC C12Q 1/688 ; CPC C12Q 1/689250 — Brain-Age IRM (SaaS) ; IPC A61B 5/055 ; CPC G06T 7/6051 — Stack Rapa + D+Q + exo ; IPC A61K 31/70 ; CPC A61P 37/0252 — Patch exosomes cutané ; IPC A61K 35/51 ; CPC A61K 35/50553 — Capteur NAD implantable ; IPC G01N 21/31 ; CPC G01N 21/31154 — Clock microbiome Nanopore ; IPC C12Q 1/686 ; CPC C12Q 1/689255 — Panel cytométrique IMM-AGE ; IPC G01N 33/53 ; CPC G01N 33/54356 — NAD sanguin stabilisé LC-MS ; IPC G01N 33/68 ; CPC G01N 33/689557 — mTOR pré-vaccination ; IPC A61K 31/7048 ; CPC A61P 37/0858 — MRS-NAD cérébral ; IPC A61B 5/055 ; CPC G06T 7/0059 — Triggers jeûne HRV+glycémie ; IPC A61B 5/024 ; CPC G16H 40/6760 — Patch micro-aiguilles spermidine ; IPC A61M 37/00 ; CPC A61K 31/21661 — Appli peau+grip domicile ; IPC G16H 20/20 ; CPC A61B 5/0062 — Glycan-age & perte de poids ; IPC G01N 33/68 ; CPC C07K 14/0063 — Kit urinaire 8-oxo-Gsn ; IPC G01N 30/72 ; CPC G01N 33/6864 — IL-7 pré-vaccination ; IPC A61K 38/00 ; CPC A61P 37/0865 — Blocage CCR5 anti-SASP ; IPC A61K 31/506 ; CPC A61P 37/0666 — MetaboAge LC-MS ; IPC G01N 30/86 ; CPC G01N 33/6867 — Kit AGEs CML/pentosidine ; IPC G01N 33/68 ; CPC G01N 33/689568 — Marche 4 m smartphone ; IPC A61B 5/11 ; CPC G16H 20/2069 — Indice sommeil/HRV circadien ; IPC A61B 5/024 ; CPC G16H 40/6770 — HRT guidée par glyco-âge ; IPC G16H 50/20 ; CPC A61P 19/0271 — Monitoring reprogrammation ; IPC G16H 50/20 ; CPC G06N 20/0072 — Multivitamines QA longévité ; IPC A61K 31/00 ; CPC A61K 31/0073 — Coach sommeil basique ; IPC G16H 40/20 ; CPC G16H 40/6774 — Dosage AOPP spectro ; IPC G01N 33/68 ; CPC G01N 33/6875 — Classic Age Analytics (GBM) ; IPC G16H 50/20 ; CPC G06N 20/0076 — Boîtier ATEX pour capteurs ; IPC H05K 7/14 ; CPC H05K 7/1477 — Registre consentement & data ; IPC G16H 10/60 ; CPC G06F 21/62 Keywords telomere, qPCR, standardization, epigenetic clock, methylation, pipeline, federated learning, privacy, biological age, p16, T cells, immunosenescence, SASP, cytokines, multiplex, proteomics, age model, ELISA, IgG glycan, UPLC, DBS, autofluorescence, skin AGE, optical, pulse wave, PPG, arterial stiffness, VO2max, submax test, smartphone, gait, IMU, frailty, NAD, lactate-pyruvate, CD38, NMN, apigenin, chronotherapy, senolytics, fisetin, quercetin, microneedle, transdermal, senolytic, autophagy, spermidine, HIIT, mitochondria, CoQ10, lipoic acid, brown fat, thermography, cold, thymus, IL-7 surrogate, TRIIM, plasma exchange, albumin, NfL, microbiome, FMT, prebiotic, composite age, multi-omics, ML, DBS, stabilization, preanalytics, MLOps, calibration, drift, retinoid, sunscreen, fractional laser, dietary AGEs, recommendation, feedback, MRI, segmentation, thymus, digital biomarker, voice, HRV, autofluorescence, smartphone, skin, NAD, reinforcement-learning, dosing, autophagy, fingerstick, LC3, respirometry, oxygen, lab-on-chip, PWV, handgrip, adapter, CBC, hematology, age index, IL-6, CRP, workflow, aptamer, proteomic clock, QC, transcriptomic, RNA-seq, age, microbiome, 16S, age clock, CHIP, cfDNA, dPCR, mtDNA, copy number, deletions, cortisol, melatonin, patch, hormesis, sauna, polyphenols, glycan-age, coaching, IgG, CD38, nanoparticle, NAD, CAR-T, uPAR, senescence, OSKM, AAV, partial reprogramming, transformer, explainable AI, multimodal, wearable, NAD sensor, microfluidic, epigenetic chip, fingerstick, mobile, brain-age, MRI, domain adaptation, rapamycin, senolytics, exercise, exosome, hydrogel, skin, implantable, fluorescence, NAD, nanopore, microbiome, age, immunosenescence, flow cytometry, IMM-AGE, NAD, LC-MS, preanalytics, MRS, NAD, brain, HRV, fasting, closed-loop, microneedle, spermidine, transdermal, skin-AGE, grip, app, glycan-age, weight-loss, UPLC, 8-oxo-Gsn, urine, HPLC-MS, IL-7, vaccination, thymic, CCR5, maraviroc, SASP, metabolomics, age-model, LC-MS, CML, pentosidine, AGEs, gait-speed, smartphone, frailty, sleep, HRV, circadian, HRT, glycan-age, menopause, OSKM, monitoring, epigenetic, multivitamin, QC, SPC, sleep-hygiene, coaching, PSQI, AOPP, oxidative-stress, spectrophotometry, gradient-boosting, SHAP, calibration, ATEX, enclosure, ruggedization, consent, FHIR, governance