ETIOPATHOGENESIS OF TROPHIC ULCERS IN CHRONIC VENOUS INSUFFICIENCY

Chronic venous insufficiency of the lower extremities is extremely common in the modern world. It is defined as the presence of symptoms of venous stasis due to reverse blood flow in the veins (reflux) or narrowing or obstruction of the veins. Trophic ulcers are a serious complication of chronic venous insufficiency in the adult working population. It has been established that trophic ulcers in the setting of varicose veins of the lower extremities occur in 1-3% of the population of industrialized countries. Trophic venous ulcers (TVU) account for more than 70% of all lower extremity ulcers. Their occurrence in the vast majority of observations (more than 55%) is due to varicose veins and only in 15% of cases - post-thrombophlebitic syndrome. Despite the existence of new treatments, the recurrence rate remains in the range of 20-70%. Therefore, for the effective treatment of trophic ulcers of venous etiology, it is necessary to clearly understand the etiology and pathogenesis of this pathology and to apply a comprehensive approach aimed at the known etiopathogenetic links in their treatment.