Formulation and Evaluation of Paracetamol Matrix Tablet Using Natural Polymer

Matrix tablets of Paracetamol were prepared utilizing natural polymer chitosan. The tablets represented sustained drug release which is required for the drugs like Paracetamol with low bioavailability and low half life. The tablets can sustain the drug release which can overcome such problems. Moreover the tablets contain chitosan which also is a permeability enhancer and hence could be utilized to increase the permeability of the drugs like Paracetamol with very low permeability. The tablets possess high potential for being developed as sustained release dosage forms for drugs with low permeability , bioavailability and lower half life.