Silver Nanoparticle-Antibiotic Combinations for Combatting Antimicrobial Resistance: A Review

Antimicrobial resistance (AMR) is becoming a serious global health issue, undermining the effectiveness of traditional antibiotics and pushing us to seek new treatment options. Silver nanoparticles (AgNPs) have gained a lot of attention due to their strong and wide-ranging antimicrobial properties. When used alongside conventional antibiotics, AgNPs can create a powerful synergy, boosting antibacterial effectiveness, slowing down the development of resistance, and enhancing treatment success against multidrug-resistant pathogens. This review delves into silver nanoparticles: synthesis, characterization and factors that affect their synthesis, applications, antimicrobial resistance, their function as antimicrobial agents, their combinations with antibiotics, and also what the future might hold. As major challenges abound in integrating AgNPs with antibiotics to tackle AMR, this approach offers a promising way to revive the potency of existing antimicrobial treatments. To fully unlock the potential of this innovative strategy in fighting resistant infections, more research is needed, particularly in clinical trials, biocompatibility, and targeted delivery systems