Oral Thin Films as Placebo Substrate: Current Innovation in Printing Technology

Printing technology is a rising innovation with the quickest beginning in the oral thin film manufacturing techniques. While the printing technology already enables a precise dosing of fluids, there is still a high need of suitable, edible substrate with required loading capacity. Other Oral Solid dosage forms lacks some applications such as personalised medication, minimizing dosing, enhancing productivity and increase cost effectivity as application. Drug loaded printing ink was developed with their optimized properties and printing was carried out on the placebo substrate i.e oral thin film. New manufacturing techniques were used for formulation of printed oral thin films are related to the drop on demand technology, flexographic method extrusion-based methodology which mainly includes the semi-solid extrusion (SSE) and the fused deposition modelling (FDM) based 3D printing. This review give the overview of oral thin films used as placebo substrate for the preparation of printed oral thin films, their method preparation, for introduce some 2D printing technologies suitable for pharmaceutical manufacturing and their applications to the development of printed oral thin films.