Clinical Profile and Outcome of Sepsis in patients admitted in Medical ICU and its correlation with SOFA Score

Abstract Aim: The current study was planned to assess clinical profile of sepsis patients admitted in ICU and to correlate the outcome of patients with the SOFA Score. Methods: This was a prospective observational study in patients admitted with sepsis of any etiology at Medical Intensive Care Unit (MICU) of tertiary care hospital, Bhopal during the period of 18 Months. SOFA score was assessed and outcome was recorded at intervals of 0,3,7,14 and 28 days in terms of recovery or mortality from the day of admission. Data was analyzed using software IBM SPSS ver. 25 and presented as mean ± standard deviation & p value of less than 0.05 was considered significant. Results: A total of 200 patients were enrolled in the study. Mean age was 54 ± 15 years, with male predominance (67.5%). Pneumonia was identified as the most common cause of sepsis. Presence of one or more co-morbidity was associated with high mortality. High mortality was observed in elderly patients (45%) and males (72%). When SOFA score was correlated with outcome of sepsis in study population it was observed that the patients admitted with lower SOFA score had better outcome compared to those who were admitted with or progressed to higher SOFA score during the hospital stay. Conclusion: SOFA score is a reliable indicator to predict the outcome in sepsis patients at admission in ICU. Correlation of SOFA score with outcome of sepsis at admission and at frequent intervals should be done to assess clinical recovery of patients.