Exploring The Therapeutic Potential of Sea Buckthorn Enriched Polyherbal Oil Formulation for Alleviating Diabetic Neuropathy Pain

Diabetic neuropathy is a chronic complication of diabetes that leads to nerve damage and persistent pain. Conventional pharmacological treatments provide symptomatic relief but often lead to side effects and limited long-term efficacy. This study focused on formulating and evaluating a polyherbal oil as a natural alternative for managing diabetic neuropathy pain. The formulation incorporated bioactive ingredients such as sea buckthorn oil, Ashwagandha, mahanarayan oil, curcumin, camphor, and peppermint oil, known for their antioxidant, anti Inflammatory, and neuroprotective properties. The study involved conducting preliminary phytochemical screening to identify key active constituents responsible for the antioxidant and anti-inflammatory effects. Formulations were developed with varying compositions and subjected to physicochemical evaluation, including viscosity, spreadability, pH, and stability analysis. Analytical assessments such as total phenolic content (TPC) measurement was conducted to determine antioxidant activity. The results demonstrated that the polyherbal oil possesses promising antioxidant properties, supporting its potential as a safe and effective alternative to synthetic treatments for diabetic neuropathy. However, further in vivo studies and clinical trials are required to confirm its mechanism of action, long-term stability, and therapeutic efficacy.