A Review on Liquisolid Technique

The majority of therapeutic agents have found oral medication administration to be most preferable and commonly usefull delivery technique. Because it is so convenient, easier to administer, and improves patient compliance, it is one of the most often utilized medication delivery methods. Dissolution rates, which are regulated by the effective surface area available for dissolution, restrict the bioavailability of several weakly water-soluble medications. One of the hardest parts of drug research is still making poorly water-soluble medications more oral bioavailable. The more modern "powdered solution technology" & "liquisolid technology" used in create rapid-release solid dosage forms from water-insoluble medications. When developing the perfect solid dosage form unit, industry faces a difficult problem: the restricted solubility of pharmaceuticals. The liquisolid method is a new and promising way to deal with this effect. The method's foundation is breakdown of non-volatile solvent for an insoluble drug, followed the addition in a suitable coating & carrier materials to drug-loaded solutions to create powders that flow and compress well. Individual chemical components have no bearing on the choice of the proportion of nontoxic hydrophilic solvent, carrier ingredient, and coating ingredient. Higher bioavailability can be attributed to either increased drug particle wettability, greater water solubility of drug, or enhanced drug surface area for accessible release