Design Synthesis and Characterization of Chloramphenicol Cocrystals

Chloramphenicol, a broad-spectrum antibiotic, suffers from poor aqueous solubility and bioavailability, limiting its therapeutic efficacy. To address this challenge, we designed and synthesized chloramphenicol cocrystals with co-former, including caeffine. The cocrystals were characterized using UV Spectroscopy, and Fourier transform infrared spectroscopy, Differential Scanning Colorimetry, HPLC. The solubility and dissolution rate of the cocrystals were significantly improved compared to the pure drug.These results demonstrate the potential of cocrystal formation as a strategy to improve the solubility, and therapeutic efficacy of chloramphenicol. The co-crystals were synthesized using the solvent evaporation method, where Chloramphenicol and caffeine were dissolved in a solvent mixture and allowed to crystallize as the solvent evaporated. The synthesis was confirmed using advanced techniques, which revealed a new crystalline structure distinct from the pure drug and coformer.