Hepatoprotective and Antioxidant Effects of Mucuna pruriens Leaves Against Paracetamol-Induced Hepatotoxicity in Albino Wistar Rats

The present study was planned to evaluate the hepatoprotective and antioxidant potential of Mucuna pruriens leaves and to evaluate its therapeutic efficacy in managing hepatotoxicity. Rats weighing 200–250 g were assigned into six groups (n = 6), normal saline only (control), normal saline (NS), Hydroalcoholic extract of Mucuna pruriens leaves (HAMP) (100, 200 and 400 mg/kg) and Silymarin (100 mg/kg) treated orally for five days, paracetamol (PCM) was administered via intra-peritoneal route, biochemical and histology parameters were determined in serum and liver. This research revealed that treatment with HAMP reversed the elevation of liver enzymes such as AST, ALT & ALP, liver SOD, GSH, and CAT were elevated in HAMP and Silymarin groups. The hepatic histological lesions in HAMP were reduced in a dose-dependent manner. This research shows that HAMP attenuates the deleterious effect of paracetamol-induced liver toxicity in rats.