CLOPIDOGREL MONOTHERAPY TO TREAT DOUBLE-RISK ACUTE CORONARY SYNDROME AND ALSO SHOW DIFFERENCE CLOPIDOGREL VS DAPT IN ACUTE CORONARY SYNDROMES WITH HIGH BLEEDING RISK

Background: Acute Coronary Syndrome or ACS is a medical condition which includes increased risk of ischemic terminologies. This standard type of therapy often includes Dual Antiplatelet Therapy or DAPT, it comprises of aspirin and some inhibitors like P2Y12 such as clopidogrel. Moreover, that DAPT increases risk of bleeding, it includes those patients who have specially both high ischemic and bleeding risks, we also named them as double-risk patients. Some recent studies demonstrate that it is proposed of clopidogrel monotherapy which work as a potentially and conditionally safer alternative in this population. Aims: This article aims to examine out the effectiveness and safe way of clopidogrel monotherapy in patients with double-risk or ACS patients. It compares out some terms between clopidogrel monotherapy and DAPT in those patients which includes high ischemic or poor supply of oxygen and blood and also bleeding risk issues. Methodology: A systematic and research based studies show that meta-analysis of some randomized controlled trials and other observational studies which were collected from major medical databases and it were conducted among these patients. That data was extracted on some major and adverse cardiovascular events, other bleeding events and increased rate of mortality. Results: Clopidogrel monotherapy was associated with some superior rates of MACE by comparing it to DAPT in selection of high-risk populations, while it is significantly reducing some major bleeding incidents. Moreover, selection criteria of patient’s and timing of therapy cessation were harsh to determine and also other determinants of clinical outcomes. Conclusion: This Clopidogrel monotherapy presents some other workable options for double-risk of patients with ACS, it offers a balance between protection of thrombotic nerve and increased risk of bleeding. Other large-scale studies are necessary to refine patient’s selection and it optimize its therapeutic strategies. Keywords: syndrome, therapeutic, thrombotic, nerve impulse.