Isolation, Phytochemical Investigation, Evaluation and Formulation of Antibacterial Herbal Gel Containing Grewia Tiliifolia Leaf Extract

This study aimed to develop an antibacterial gel using the leaves of Grewia tiliifolia, a plant well-known for its antibacterial properties due to the presence of flavonoids and triterpenoids. The plant is easily accessible and cost-effective, offering a variety of beneficial effects, including antioxidant, antibacterial, antimicrobial, wound-healing, anticancer, analgesic, and antidiabetic properties. The gel formulations were made using the dried ethanolic extract of Grewia Tiliifolia leaves. The herbal gel was created by combining these ethanolic extracts with the polymer carbapol 934. It’s physiochemical characteristics including pH, appearance, Homogeneity, viscosity, spreadability and potential for skin irritation, were then assessed. The agar well diffusion assay was utilized to check the gel antibacterial properties against the staphylococcus aureus bacteria. At various concentration of 25 µg, 50 µg, 75 µg, and 100 µg, the distinct herbal gels showed antibacterial activity against Staphylococcus aureus, exhibiting inhibition zones of 12ՠՠ, 14ՠՠ, 18ՠՠ, and 20ՠՠ, respectively.