Nephroprotective Activity of Bougainvillea Glabra Linn. On Gentamicin -Induced Nephrotoxicity In Wistar Albino Rats

Objective: Herbal and polyherbal formulations are at boom owing to lesser side effects and higher efficacy and are considered for management of renal complications. To evaluate the Nephroprotective activity of Bougainvillea glabra flower extract against Gentamicin -induced nephrotoxicity in rat model. Methods: Nephrotoxicity were induced in wistar rats of either sex by intraperitoneal administration of Gentamicin 100mg/kg body weight for eight days. The methanolic extract of Bougainvillea glabra (L.) flower (250, 500 mg/kg) administered orally to Gentamicin treated rats for next eight days. Rats were subjected to evaluate biochemical and general parameters and histopathology of renal tissue were performed at the end of 9 days after 8 days treatment. Results: The elevated serum createnine, blood urea nitrogen levels, urine createnine, urine volume, kidney weight Gentamicin treated rats were reverted back approximately near to normal after the treatment of Bougainvillea glabra (L.) flower at a doses of 250 and 500 mg/kg. Conclusion: Bougainvillea glabra (L.) flower possesses protective action against Gentamicin induced nephrotoxicity in wistar rats which may be attributed by its antioxidant effect.