Personalized exercise regimens in post-stroke rehabilitation: optimizing blood pressure variability and functional independence

On the basis of the high prevalence and disabling character of stroke, individualized rehabilitation regimens are a critical strategy for improving the outcome in the clinical situation. The current study aims to investigate the impact of individualized training protocols on blood pressure variability (BPV) and functional independence among stroke patients at the recovery stage in Uzbekistan. In the quasi-experimental study, 100 patients with a history of ischemic or hemorrhagic stroke within the previous 6 months will be randomly allocated to two control and intervention groups. The intervention group will receive a combined exercise program (balance, resistance, and aerobic) tailored according to their clinical status, degree of disability, and blood pressure profile, and the control group will undergo a standard rehabilitation program. Assessments are also made by daily BPV measurement with wearable devices, functional tests (Barthel index and 10-meter walk time), and observation of cardiovascular complications for 12 weeks. Initial data analysis results showed the significant reduction of systolic blood pressure variability (15.2 ± 3.8 mmHg to 8.9 ± 2.1 mmHg; p=0.002) and functional independence score improvement by 40% in the intervention group versus the control group. These findings underscore that customized exercise programs not only reduce the risk for secondary cardiovascular complications by BPV modulation but also improve post-stroke quality of life by enabling early return to daily activities. Within the Uzbek health care system, the introduction of similar interventions, given ethnic heterogeneity and limited access to high-tech technologies, necessitates the implementation of local evidence-based procedures.