Formulation and Evaluation of Stavudine Floating Tablet

The present study was conducted to develop floating matrix tablets of Stavudine with the objective of extending its gastric retention time and evaluating the effect of various polymers on drug release behavior. Tablets were formulated using the melt granulation method, incorporating beeswax as a hydrophobic binder. Hydroxypropyl methylcellulose (HPMC) was used as the matrix-forming polymer, sodium bicarbonate as the effervescent agent to induce buoyancy, and ethyl cellulose as a floating enhancer. Compatibility and interaction between the drug and excipients were studied using Differential Scanning Calorimetry (DSC) and Fourier Transform Infrared Spectroscopy (FTIR).