Formulation And Evaluation of Cimetidine Floating Tablet

Among the more promising GRDS is the Floating Drug Delivery System (FDDS). Beneficial, FDDS improves stomach retention and boosts the effectiveness of medical treatment. With oral dose, site-specific delivery, sustained release, delayed release, and instant release have all advanced significantly. Gastric ulcers and gastro-oesophageal reflux disease (GERD) are commonly treated with cemetidine, a histamine H₂-receptor antagonist. The 1970s saw the discovery of the first H₂ blocker. To increase its bioavailability, a gastroretentive drug delivery method must be developed due to its brief biological half-life and limited window for absorption in the upper gastrointestinal tract. Several hydrophilic polymers, including carbopol and hydroxypropyl methylcellulose (HPMC), were used in the formulation of floating tablets of cimetidine in this study in order to increase the duration of stomach retention. The buoyancy was achieved by adding sodium bicarbonate as a gas-generating agent. In vitro buoyancy, in vitro drug release, hardness, friability, drug content, and physical appearance were among the factors that were assessed for the tablets. A non-Fickian diffusion mechanism was used to explain the optimised formulation’s sustained drug release over 12 hours and floating lag time of less than one minute. According to this study, the distribution of cimetidine and possibly other medications with comparable absorption properties may be facilitated by floating tablets. A prototype medication for H2-receptor antagonists is cimetidine.