Formulation And Evaluation of a Mimosa Pudica Leaf Extract-Based Transdermal Patch Foranti-Inflammatory Activity

The present study focuses on the formulation and evaluation of a transdermal drug delivery system (TDDS) incorporating Mimosa pudica extract, a plant known for its potent anti-inflammatory properties. Transdermal patches offer numerous advantages over conventional drug delivery, including sustained release, improved patient compliance, and avoidance of first-pass metabolism. In this work, Mimosa pudica leaves were extracted using methanol, followed by preliminary phytochemical screening to identify bioactive constituents. Transdermal patches were prepared using the solvent casting technique, with various concentrations of polymers such as HPMC and PVP, and plasticizers like PEG 400. The formulated patches were evaluated for physicochemical parameters including thickness, weight uniformity, folding endurance, moisture content, drug content, and in vitro drug release. Among all formulations, F3 showed optimal performance with satisfactory drug release over 8 hours and good mechanical properties. The study concludes that Mimosa pudica can be effectively delivered through a transdermal patch, offering a promising herbal approach to anti-inflammatory therapy.