A Systemic Review on Plant Based Anti-Inflammatory Agents

Anti-inflammatory drugs are used widely to reduce inflammation that is involved in various diseases such as Alzheimer, Parkinson, rheumatoid arthritis, asthma, infectious diseases including COVID-19 infections, etc. These drugs are used for acute as well as for chronic conditions. The well-known anti-inflammatory drugs that are available in the market are nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, naproxen, diclofenac, celecoxib, etc. The steroids are also used as anti-inflammatory agents especially in chronic and severe inflammation; however, long-term use of steroids is associated with various adverse drug reactions (ADRs). Thus, there is a need of more safe and efficacious anti-inflammatory drugs in the treatment of various diseases. Many anti-inflammatory drugs are under experimental investigation and some of them are in different phases of clinical trials. This chapter summarizes the information related to ongoing and completed clinical trials of anti-inflammatory drugs in various diseases along with their future perspectives.