Regeneration of pulp using stem cells for oral health renewal: A literature review

Introduction: Root canal treatment is often the last resort for managing severe pulp damage. However, current conventional therapies only focus on replacing damaged tissue without any attempt to regenerate biological tissue. Dental pulp stem cell (DPSCs)-mediated pulp regeneration has emerged as an innovative solution. Methods: This study involved analyzing references from journals and textbooks within the timeframe 2020-2024 to explore the potential of DPSCs in pulp regeneration. Discussion: DPSCs possess remarkable regenerative potential with their ability to differentiate into various essential cell types. They also support angiogenesis and neurogenesis to repair pulp tissue. While challenges such as standardization and integration with host tissue exist, research continues to enhance the safety and efficacy of the therapy. Conclusion: Pulp regeneration using DPSCs offers a natural and effective approach to dental care. Despite remaining obstacles, this research provides a foundation for regenerative therapies that could transform endodontic practices and improve patient well-being.