THERAPEUTIC IMPLICATION OF SEA BUCKTHORN IN ALLEVIATING VASCULAR DEMENTIA ASSOCIATED WITH ESTROGEN DEFICIENCY IN POST-MENOPAUSAL WOMEN: PRE-CLINICAL TO CLINICAL PROGRESS

Vascular dementia (VaD) is a neurological condition associated with estrogen insufficiency, especially in postmenopausal women, and is frequently brought on by cerebral ischaemia. It entails a steady loss in cognitive function brought on by inflammation, oxidative stress, and vascular dysfunction. Current therapies mostly deal with symptoms, which emphasises the need for creative approaches that focus on the underlying causes of the illness. With its abundance of bio actives such as flavonoids (isorhamnetin, quercetin), vitamins, and polyphenols, sea buckthorn (Hippophae rhamnoides) has the potential to be used as a natural remedy. These substances support vascular health and have neuroprotective, anti-inflammatory, and antioxidant qualities. Sea buckthorn is very promising for treating VaD-related disease because of mechanisms like nitric oxide increase, PI3K/Akt pathway. Sea buckthorn's capacity to lower inflammation, enhance synaptic repair, and preserve cerebrovascular integrity is supported by preclinical data. Its function in modulating the gut-brain axis also emphasises its wider neuroprotective potential. Standardised formulations, improved bioavailability, and carefully planned human studies are necessary to translate these discoveries into practical practice. For postmenopausal women in particular, sea buckthorn offers a natural and safe way to manage vasodilator dysfunction. With more investigation, it might develop into a viable treatment option for this crippling illness.