Supplementary code availability
# QBF: Quantum Biological Field Framework for Mechanistic Prediction of IDP Diseases This project implements **QBF (Quantum Biological Field)** framework to uncover **disease-driving mechanisms** and **pathogenic sites** in **intrinsically disordered proteins (IDPs)**. ## Features - **Mechanism-Oriented** Predicts disease-specific conformational transitions and pathogenic residue hotspots. - **Theoretical Integration** Embeds residue-pair interactions for iterative refinement of hidden-state distributions. - **No Retraining Required** Generalizes across IDP families and disease variants without retraining, using only sequence input. - **Experimentally Validated** Predictions are supported by site-directed mutagenesis, aggregation assays, and Alzheimer’s disease models.
Institutions
- Stanford University (US)
Publication Details
- Journal
- Zenodo (CERN European Organization for Nuclear Research)
- Published
- 2025-04-15
- DOI
- https://doi.org/10.5281/zenodo.15757882
- Primary Topic
- Psychometric Methodologies and Testing
- Type
- article
- Field-Weighted Citation Impact
- 0.00