Supplementary code availability

# QBF: Quantum Biological Field Framework for Mechanistic Prediction of IDP Diseases This project implements **QBF (Quantum Biological Field)** framework to uncover **disease-driving mechanisms** and **pathogenic sites** in **intrinsically disordered proteins (IDPs)**. ## Features - **Mechanism-Oriented** Predicts disease-specific conformational transitions and pathogenic residue hotspots. - **Theoretical Integration** Embeds residue-pair interactions for iterative refinement of hidden-state distributions. - **No Retraining Required** Generalizes across IDP families and disease variants without retraining, using only sequence input. - **Experimentally Validated** Predictions are supported by site-directed mutagenesis, aggregation assays, and Alzheimer’s disease models.

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2025-04-15
DOI
https://doi.org/10.5281/zenodo.15757882
Primary Topic
Psychometric Methodologies and Testing
Type
article
Field-Weighted Citation Impact
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Supplementary code availability

Zenodo (CERN European Organization for Nuclear Research)
Psychometric Methodologies and Testing
article

Supplementary code availability

article en

Abstract

# QBF: Quantum Biological Field Framework for Mechanistic Prediction of IDP Diseases This project implements **QBF (Quantum Biological Field)** framework to uncover **disease-driving mechanisms** and **pathogenic sites** in **intrinsically disordered proteins (IDPs)**. ## Features - **Mechanism-Oriented** Predicts disease-specific conformational transitions and pathogenic residue hotspots. - **Theoretical Integration** Embeds residue-pair interactions for iterative refinement of hidden-state distributions. - **No Retraining Required** Generalizes across IDP families and disease variants without retraining, using only sequence input. - **Experimentally Validated** Predictions are supported by site-directed mutagenesis, aggregation assays, and Alzheimer’s disease models.

Zenodo (CERN European Organization for Nuclear Research)
Stanford University (US)
Partnerships for the goals
Openalex Percentile: Top 47%
Psychometric Methodologies and Testing
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