EFFECTIVENESS OF TAMPALA BAJAKAH WOOD (SPATHOLOBUS LITTOTALIS HASSK) ETHANOL EXTRACT IN WOUND HEALING: PRECLINICAL TEST

Abstract Objective: Analyze the effectiveness of tampala bajakah wood (Spatholobus littoralis Hassk) ethanol extract on wound healing through preclinical trials. Method: Study using a literature review approach based on national and international scientific journals regarding the effectiveness of Bajakah Tampala stem (Spatholobus Littoralis Hassk) ethanol extract on wound healing. Published between 2018 - 2023 in several databases, namely the PubMed, Science Direct, Scilit, Google Scholar, and Semantic Sholar databases with keywords using Indonesian and English with the keywords bajakah tampala, secondary metabolites, and wounds. This literature review was compiled by searching scientific articles with the keyword "effectiveness of tampala bajakah wood (Spatholobus Littoralis Hassk) ethanol extract in wound healing" and 124 articles were found. Results: Five articles were found that met the inclusion criteria. five articles examined secondary metabolite compounds in the Bajakah tampala plant (Spatholobus Littoralis Hassk) with 96% ethanol extract and one article used 70% ethanol extract for wound healing. Previous research showed that the results of the 96% extra ethanol phytochemical screening test for Bajakah Tampala (Spatholobus littoralis Hassk) contained secondary metabolites, namely alkaloids, flavonoids, saponins, terpenoids, phenolics and tannins. Furthermore, other research used 70% extra ethanol containing secondary metabolites of flavonoids, saponins, steroids, terpenoids, tannins and phenols. But it does not contain alkaloid compounds. Extra 70% ethanol heals wounds in male white rats. Conclusion: The incision area of male white rats smeared with ointment-based 70% ethanol extract had a relatively better healing time (10%) than the area smeared with 20% and 40% concentration extract.