Potential use of Alpha Klotho in Relation to Oxidative Stress in Chronic Obstructive Pulmonary Disease (COPD): A Systematic Review

Objectives: Chronic Obstructive Pulmonary Disease (COPD) is associated with ongoing inflammation, overuse injury, and accelerated aging of the lungs. Alpha Klotho is an anti-aging protein that protects cells from inflammation and damage. Alpha Klotho effectively reduces oxidative stress and maintains mitochondrial function by involving the reduction of ROS (reactive oxygen species) through the expression of antioxidant proteins as well as the suppression of ROS-related oxidative stress signaling pathways. However, there is still limited research on the potential use of alpha klotho in relation to oxidative stress in COPD. The aim of this study was to determine the potential use of alpha klotho in relation to oxidative stress in COPD. Method: This research method uses the Systematic Review method by collecting secondary data from scientific research articles from 2014 - 2024. Data search used the databases PubMed, Google Scholar, Plos Medicine, Taylor and Francis, Nature. Conducted using the terms: alpha klotho, COPD, oxidative stress. Results: 2 studies were selected for Systematic Review. Shows that alpha Klotho inhibits oxidative stress and the expression of inflammatory mediators so that it can protect lung cells from inflammation and further damage in COPD. Conclusion: This review suggests that targeting the use of alpha klotho may be useful in suppressing oxidative stress that occurs in disease progression in COPD patients.