SPHERICAL CRYSTALLIZATION: AN INNOVATIVE TECHNIQUE IN THE FIELD OF PARTICLE ENGINEERING

In the manufacture of tablets, the direct compression method is frequently used. In comparison to the traditional wet granulation approach, this cannot be used with sensitive pharmaceuticals and also has a lot more processing restrictions. Spherical agglomeration is a innovative method for creating pharmaceutical dosage forms that are immediately compressible, the process of spherical agglomeration, which improves the powder's qualities such as particle size, shape, flow characteristics, solubility, and bioavailability of pharmaceutical medicinal ingredients, includes transforming tiny crystals into a spherical shape. The spherical crystallization was improved for use with hydrophilic polymers in order to improve the dissolution properties of hydrophobic drugs. The flow characteristics, particle size analysis, compression, and dissolution behavior of the spherical agglomerates were also improved. Wet spherical agglomeration (WSA) and the quasiemulsion solvent diffusion method (QESD) are the two most used methods for crystallizing spheres. Additionally, these approaches have two additions: the ammonia diffusion system (ADS) and crystallo-coagglomeration (CCA).The neutralization technique is another method used in this procedure. Any of the aforementioned methods can be used concurrently for both crystallization and agglomeration This article describe the over view of spherical crystallization along with way of optimizing the processing parameters to get effective spherical agglomerates. Keywords: Spherical agglomeration; Quasiemulsion solvent diffusion method; Ammonia diffusion system; Crystallo-co agglomeration