Benefits Of Nanoemulsion Based Nasal in Situ Gel: A Review

The benefits of the in-situ gel nasal drug delivery system based on nanoemulsions over oral administration in terms of systemic bioavailability are examined in detail in this review. A low- viscosity solution is injected into the nasal cavity using in-situ gel technology, a novel method of nasal drug delivery that turns into a gel when it comes into contact with the nasal mucosa. In comparison to traditional delivery methods, nasal drug delivery offers several advantages, such as avoiding first-pass metabolism, improving the permeability of some medications through the nasal epithelium, facilitating rapid absorption across the membrane, accelerating the onset of action, improving patient compliance and comfort, and extending the duration of drug release. Variations in temperature, pH, ion concentration, UV light, polymorphism, dissolution rate, solubility, viscosity, and osmolarity are some of the variables that variables that affect the gel formation process.