The Overall Review on Formulation, Evaluation and Different Types of Manufacturing of Oral Disintegrating Films

Oral disintegrating films (ODFs) have emerged as a novel and versatile platform in drug delivery, offering an effective alternative to conventional dosage forms, especially for populations with swallowing difficulties. These thin, flexible films rapidly disintegrate upon contact with saliva, enabling faster onset of action and eliminating the need for water, thereby enhancing patient compliance. This review provides a comprehensive overview of the evolution, formulation strategies, and key excipients involved in ODF development, alongside insights into their mechanical properties, drug loading capacities, and innovative manufacturing techniques such as solvent casting and 3D printing. Furthermore, it highlights recent advancements, regulatory considerations, and challenges related to stability, taste masking, and scalability. By bridging the gap between convenience and efficacy, ODFs are positioned to revolutionize the pharmaceutical landscape, particularly in personalized and pediatric medicine. This review aims to shed light on their potential while identifying future directions for research and commercial development.