A Review of the Article Cadasil

Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a rare hereditary small vessel disease of the brain caused by mutations in the NOTCH3 gene. Recurrent ischemic strokes, cognitive impairment, aura-accompanied migraines, mood swings, and progressive dementia are its hallmarks. Because of its inconsistent clinical presentation, CADASIL is still underdiagnosed despite growing awareness.