FORMULATION OPTIMIZATION AND INVITRO EVALUVATION OF NIACIN PROLONGED RELEASE TABLET

The objective of the present research work is to develop a pharmaceuticallystable, cost effective and quality improved formulation of “Niacin prolongedrelease matrix tablets” which is to be bioequivalent with reference product.For the preparation of niacin prolonged release tablets both directcompression and wet granulation method using various polymers such asMethocel K100M, Methocel E15LV, Pharmatose 200M, Cutina HR,Pamster and aerosol. Wet granulation method was carried out in fluidizedbed processor with optimized parameters. Tablets were prepared andevaluated for thickness, hardness, friability, weight variation, contentuniformity, and in vitro drug release. For the entire formulations similarityfactor and dissimilarity factors were calculated among all these resultsformulation 8 values are satisfied. The release kinetics of the drug wasobserved to fit best with korsmeyer peppas having regression coefficient oflinear line as 0.999 and slope was 0.65. The bottles are loaded in acceleratedstability chambers at 400C / 75 % RH conditions. Samples were analysedafter one month and two months intervals.