Two-step One-Pot Multicomponent Reaction Improved by TBAF for the Preparation of 2-Amino-3, 5-dicyano-4-aryl-6-phenylsulfanylpyridines

Abstract: To further explore TBAF's catalytic properties, a study investigated its role in the synthesis of 2-amino-3, 5-dicyano-4-aryl-6-sulfanyl-pyridines under mild conditions. Two-step One-Pot Multi-component reaction (MCR) synthesis of pyridines derivatives using TBAF as the catalyst was conducted across different organic solvents. The formation of 1a was observed in polar solvents like methanol, acetonitrile, dimethylformamide (DMF), and ethanol, with ethanol yielding the highest yield (91%). Notably, the absence of TBAF led to no product formation even after extended reaction times.