Gastroretentive Floating Tablets: Formulation And Evaluation For Site-Specific Delivery

A macrolide antibiotic called "selected drug" is frequently used to treat a variety of bacterial infections, including those brought on by Helicobacter pylori, which is linked to gastritis and peptic ulcers. [1] Even if the medicine is efficacious, its short gastric residence time and variable bioavailability due to rapid gastric emptying can seriously impair its therapeutic efficacy. Conventional oral formulations might not keep the stomach's drug levels high enough, which would result in less than ideal therapeutic results. However, quick stomach emptying may reduce its bioavailability. The therapeutic efficacy of the medication can be increased by using a gastro retentive floating tablet [2] (GFT) to lengthen the drug's retention period in the stomach. The goal of this research is to use statistical techniques to formulate and optimize a particular medicine GFT and assess its efficacy through in vitro experiments.