EFFECTS OF VITAMIN B COMPLEX SUPPLEMENTATION ON THE PREFRONTAL CORTEX OF METHAMPHETAMINE-INTOXICATED WISTAR RATS

Abstract: Methamphetamine (MA) abuse is known to have detrimental effects on brain function, particularly in the prefrontal cortex, resulting in cognitive impairments and neurotoxicity. This study aimed to examine the toxicological effects of methamphetamine on body weight and oxidative stress in rats and evaluate the protective potential of Vitamin B complex supplementation. Seven groups of rats were used: Group A (positive control) received only food and water ad libitum; Group B was induced with a low dose of methamphetamine (2 mg/kg); Group C received a high dose of methamphetamine (10 mg/kg); Group D received a low dose of Vitamin B complex (50 mg/kg); Group E was given a high dose of Vitamin B complex (100 mg/kg); Group F was induced with methamphetamine (10 mg/kg) and treated with a low dose of Vitamin B complex (50 mg/kg); and Group G received methamphetamine (10 mg/kg) along with a high dose of Vitamin B complex (100 mg/kg). Body weight and oxidative stress markers were assessed after the treatment period. Results indicated that methamphetamine-induced groups (B and C) showed significant weight loss and increased oxidative stress, suggesting neurotoxic effects. However, the groups co-treated with Vitamin B complex (Groups F and G) exhibited improvements in body weight and a reduction in oxidative stress, approaching the control group levels. These findings suggest that Vitamin B complex, with its antioxidant properties, may mitigate the neurotoxic effects of methamphetamine. This study highlights the potential of Vitamin B complex as a protective agent against methamphetamine-induced damage to brain function and body weight regulation. Keywords: Methamphetamine, Vitamin B complex, oxidative stress, prefrontal cortex, addiction. Title: EFFECTS OF VITAMIN B COMPLEX SUPPLEMENTATION ON THE PREFRONTAL CORTEX OF METHAMPHETAMINE-INTOXICATED WISTAR RATS Author: Okafor Emeka Christian, Ezeokafor Emmanuel Nonso, Dr Bernard Omuwa Osazuwa, Dr Akor Ekele Benjamin, Nwankwo Samuel Ikwunne, Nwanaga Clinton Uche International Journal of Recent Research in Life Sciences (IJRRLS) ISSN 2349-7823 Vol. 12, Issue 1, January 2025 - March 2025 Page No: 56-64 Paper Publications Website: www.paperpublications.org Published Date: 10-March-2025 DOI: https://doi.org/10.5281/zenodo.14999008 Paper Download Link (Source) https://www.paperpublications.org/upload/book/EFFECTS%20OF%20VITAMIN%20B%20COMPLEX%20SUPPLEMENTATION-10032025-3.pdf