Review on Bilayer Tablets

Bi-layer tablets are essential for developing both immediate and modified drug delivery systems for various diseases. They facilitate controlled medication release, representing a significant advancement in Controlled Drug Delivery Systems (CDDS) and improving the effectiveness of medication delivery. Over the past 30 years, the complexity and costs of introducing new drugs have increased, leading to greater focus on sustained or controlled release systems. Bi-layer tablets enable precise delivery of medications with predetermined release profiles, preventing chemical incompatibilities between Active Pharmaceutical Ingredients (APIs). This technology supports combination therapies for conditions like hypertension, diabetes, and pain relief. Many pharmaceutical companies are investing in bi-layer tablet development for advantages such as patent extension and marketing opportunities. This review discusses bi-layer tablet technology, manufacturing challenges, the types of tablet presses used, and the relevant quality and Good Manufacturing Practice (GMP) standards. Additionally, it covers recent advancements in the field.[3].