A CASE REPORT ON NEUROMYOTONIA ASSOCIATED WITH MYASTHENIA GRAVIS: ISAACS SYNDROME

This case report details a 38-year-old male presenting with symptomsincluding muscle twitching, cramps, and bilateral ptosis. He wasdiagnosed with neuromyotonia (Isaacs syndrome) alongside myastheniagravis (MG), indicated by the presence of serum acetylcholine receptor(AChR) antibodies. The patient showed significant improvement after a5-day course of intravenous methylprednisolone and phenytoinadministration. This case suggests overlapping pathophysiologicalmechanisms between neuromyotonia and autoimmune myastheniagravis, warranting further research.Keywords: Neuromyotonia, Isaacs syndrome, Myasthenia gravis,Acetylcholine receptor antibodies, Autoimmune disorders, Peripheralnerve hyperexcitability

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2024-12-25
DOI
https://doi.org/10.5281/zenodo.15107626
Primary Topic
Ocular Diseases and Behçet’s Syndrome
Type
article
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article

A CASE REPORT ON NEUROMYOTONIA ASSOCIATED WITH MYASTHENIA GRAVIS: ISAACS SYNDROME

Zenodo (CERN European Organization for Nuclear Research)
Ocular Diseases and Behçet’s Syndrome
article

A CASE REPORT ON NEUROMYOTONIA ASSOCIATED WITH MYASTHENIA GRAVIS: ISAACS SYNDROME

article en

Abstract

This case report details a 38-year-old male presenting with symptomsincluding muscle twitching, cramps, and bilateral ptosis. He wasdiagnosed with neuromyotonia (Isaacs syndrome) alongside myastheniagravis (MG), indicated by the presence of serum acetylcholine receptor(AChR) antibodies. The patient showed significant improvement after a5-day course of intravenous methylprednisolone and phenytoinadministration. This case suggests overlapping pathophysiologicalmechanisms between neuromyotonia and autoimmune myastheniagravis, warranting further research.Keywords: Neuromyotonia, Isaacs syndrome, Myasthenia gravis,Acetylcholine receptor antibodies, Autoimmune disorders, Peripheralnerve hyperexcitability

Zenodo (CERN European Organization for Nuclear Research)
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Ocular Diseases and Behçet’s Syndrome
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A CASE REPORT ON NEUROMYOTONIA ASSOCIATED WITH MYASTHENIA GRAVIS: ISAACS SYNDROME · Zenodo (CERN European Organization for Nuclear Research) (2024) | TGRS Research Map | TGRS