Comprehensive Review on Ethosomes: A Novel Vesicular Approach for Topical Drug Delivery

The most successful novel drug delivery research area was the transdermal route, which was in competition with oral treatment. In recent years, there has been an increased interest in the utilization of lipid vesicles in skin therapy delivery systems. The transdermal drug delivery system's primary goal is to penetrate the stratum corneum. The vesicular system is among the most contentious approaches to transdermal medication delivery. Ethosomes are non-invasive delivery vehicles that allow medications to enter the systemic circulation or the deep layers of the skin. Ethosomes are a unique and inventive vesicular system. Ethosomes are composed of phospholipid, alcohol, polyglycol and water. Ethanol enhances skin permeability, facilitating deeper drug delivery into the underlying skin layers. Ethosomes are easy to make and safe to utilize, and their existence makes these systems more effective at delivering chemicals to the skin. The primary goal of this review article is to offer comprehensive insights into ethosomes including their mechanism of penetration, vesicular systems, types of ethosomes, preparation, composition, characterization, advantages, ethosomal dosage forms, application and marketed formulation of ethosomes.