A Study of Thyroid Function Test in Cirrhosis of Liver and Its Correlation with Severity of Liver Disease in A Tertiary Care Centre of Kolkata

Abstract Background: Cirrhosis of liver is defined as a stage of progressive hepatic fibrosis characterised by distortion of hepatic architecture and formation of regenerative nodules. Liver plays an important role in thyroid hormone activation and inactivation, transport, and metabolism, as well as the synthesis of thyroid binding globulin. Conversely, thyroid hormones have widespread systemic actions involving all organ systems. A complex relationship exists between thyroid and liver in health and disease. Aims & objectives of the study: To study the levels of thyroid hormone in Cirrhosis of liver & its possible correlation with the severity of liver cirrhosis. Methods: 200 patients were included in this study from July 2023 to June 2024. They were classified as per Child-Turcotte-Pugh scoring after clinical assessment and investigations. Serum TSH, FT3, FT4 levels were measured for all the patients. Results: Out of 200 patients, it was found that 36 (18%) patients belonged to CTP class A, 78 (39%) patients had CTP score of class B, while maximum 86 (43%) patients belonged to CTP class C. There was significant positive correlation between CTP class and TSH values (p<0.001) with mean (SD) of CTP class A, B and C were 2.42 (0.76), 3.9 (1.02) and 5.91 (1.08) respectively. There was significant negative correlation between CTP class and FT3 values (p<0.001) and between CTP class and FT4 values (p<0.001). Conclusion: Our study found that there was significant positive correlation of serum TSH values with severity of liver cirrhosis as assessed by CTP score, while FT3 and FT4 were having significant negative correlation.