The Effect of Medical Cannabis on Neurological Disorders

Introduction: Over the centuries, cannabis has been used for recreational purposes, to produce euphoric effects. However, several studies indicate the potential of cannabis, used as a therapeutic drug. D9- tetrahydrocannabinol (THC) and cannabidiol (CBD) are the two phytocannabinoids, the basic components of cannabis, that activate receptors of the endocannabinoid system and can be used as a drug for its activation. Endocannabinoid receptors are mainly expressed on central nerve system (CNS). Materials and Methods: Detailed research was performed via the PubMed database, using the following keywords: THC, CBD, neurological disorders, psychotropic plant, medical cannabis. Results: The aim of this review is to highlight the effect that THC and CBD has on neurodegenerative disorders and in particular, in Parkinson Disease (PD), Alzheimer Disease (AD) and amyotrophic lateral sclerosis (ALS). Conclusion: The clinical significance of medical cannabis is great, as it may offer anti-inflammatory, anxiolytic, anti-psychotic effects and act as neuroprotective for neurodegenerative disorders.