Evaluation and Formulation of Pulsatile Drug Delivery System of Ramipril

Pulsatile Drug Delivery Systems (PDDS) are innovative time-controlled release mechanisms designed tooptimize drug delivery by synchronizing it with the body's circadian rhythm. Unlike conventional dosageforms that provide immediate or sustained drug release, PDDS ensures a rapid and targeted release after apredetermined lag phase. This approach enhances therapeutic efficacy while minimizing side effects,particularly for conditions like hypertension, asthma, and cardiovascular diseases.This study focuses on the development and evaluation of a PDDS for Ramipril, an ACE inhibitor used inhypertension management. A specialized formulation was designed to mitigate first-pass metabolism,enhance bioavailability, and align drug release with the morning surge in blood pressure. The study involvedpreformulation analysis, core and erodible tablet formulation, capsule coating, and comprehensive in-vitroand ex-vivo evaluations. Key parameters such as drug dissolution, lag time, swelling index, and stabilitystudies were assessed to optimize the release profile.The results indicate that the developed PDDS effectively regulates the controlled and time-dependent releaseof Ramipril, improving therapeutic benefits while reducing adverse effects. This formulation provides apromising approach for chronotherapeutic management of hypertension, enhancing patient compliance andtreatment efficacy.