Formulation And Evaluation of Floating Tablets of Acetazolamide

Gastro retentive drug delivery is an approach to prolong gastric residence time, there by targeting site-specific drug release in the upper gastro intestinal tract (GIT) for local and systemic effect. The present study has been a satisfactory attempt to formulate floating drug delivery system of Acetazolamide, an orally administered Carbonic anhydrase inhibitor which is used in the treatment of glaucoma with a view of improving its bioavailability and giving controlled release of drug. In the present study 6 formulations were prepared by using polymer like HPMC K100M and HPMC K15M in different concentration ratio and combination of polymer by direct compression method. Citric acid and sodium bicarbonate is used as gas generating agent. The prepared tablets were evaluated for precompression parameters like bulk density, tapped density, angle of repose, Carr’s index, Hausner’s ratio. The formulations evaluated for post compression parameters like Hardness, friability, weight variation, thickness, drug content and swelling index. All the formulations show result in acceptable range. All the twelve formulations were subjected to in-vitro buoyancy and dissolution study. Based on results obtained for pre compression parameters and post compression parameters, in-vitro dissolution study two best formulations were selected and validated. Short-term stability study was done for four best formulations.