FORMULATION AND EVALUATION OF MELT IN MOUTH SILDENAFIL CITRATE TABLETS BY USING SUPER DISINTEGRANTS

New Using the solvent evaporation approach, co-processed super disintegrants were created by integrating one super disintegrant into the particle structure of another. By using the direct compression method with CCS, Kyron T-314, physical blend, and co-processed combination of both super disintegrants in varying ratios, melt-in-mouth tablets with 25 mg of sildenafil citrate each were created. When creating melt-in-mouth tablets, disintegration time is crucial. The pills with the quickest wetting times were found to have the quickest disintegration times. Compared to tablets containing CCS alone, Kyron T-314 alone, and their physical mixes, the tablets containing co-processed super disintegrants disintegrated more quickly. Key words: Sildenafil citrate, Kyron T-314, Croscarmellose sodium, Disintegrants