IN-SILICO AND IN-VITRO PHARMACOLOGICAL EVALUATION OF SULFAMETHOPYRAZINE AS ANTI-DIABETIC AGENT

Background Of The Study: The present study aim to evaluate the Anti-diabetic property of Sulfamethopyrazine using in-silico, in-vitro, Swiss ADME and Antioxidant evaluation. Methods: The data of Sulfamethopyrazine was collected from pubmed, pubchem, google scholar. By using software’s such as pyrex and pymol, Sulfamethopyrazine was docked with Antidiabetic receptors 3OLI and 4W93. The drug was brought from Chennai in the month of April. Then in-vitro studies were performed by using Glucose uptake assay and Inhibition of endogenous glucose production methods. Antioxidant evaluation was carried out by using DPPH method. Pharmacokinetic evaluation was done by using Swiss ADME Software. Keywords: Anti-diabetic property, Sulfamethopyrazine, Docking , In-silico Method, In-vitro Method, Swiss ADME, Antioxidant evaluation, DPPH radical scavenging assay method.