Zebrafish in Neurotoxicity Research: A Comprehensive Review

Zebrafish (Danio rerio) have become a widely used model in neurotoxicity research due to their genetic similarity to humans, transparent embryos, and rapid development. This review deliberates the advantages of zebrafish for studying neurotoxic effects, methodologies used in zebrafish neurotoxicity assessments, and their applications in environmental and pharmaceutical toxicity studies. Additionally, challenges and future perspectives of zebrafish as a model for neurotoxicology are addressed. Neurodegenerative Disease Models in Zebrafish (Danio rerio) have become an increasingly popular model organism for studying neurodegenerative diseases, recognitions to their genetic similarity to humans, transparent embryos, rapid development, and ease of genetic manipulation. They offer numerous advantages over other models, including the ability to visualize the progression of neurodegeneration and the effects of potential therapeutic interventions in real time. This article will explore several key neurodegenerative disease models in zebrafish, focusing on Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS).