MODERN ASPECTS OF DIAGNOSIS IN PREMATURE AMNIOTIC FLUID RETENTION

Premature amniotic fluid retention (PAFR) remains one of the most urgent problems of modern obstetrics, as it significantly increases the risk of complications in labor. In this work we studied the pathogenesis of uterine contractile initiation disorders in PIUI, taking into account the peculiarities of steroid hormone metabolism and fetal hormonal status. We examined 193 patients divided into a control group, a main group (with PAFR) and a comparison group (with timely amniotic fluid shedding). It was found that PIOB is accompanied by hyperprogesteronemia, decreased concentration of cortisol, dehydroepiandrosterone-sulphate (DEAS) and estradiol, and insufficient oxytotic activity. These findings indicate that the biological readiness of the fetus for labor is impaired, necessitating the use of synthetic anti-gestagens and oxytocin to stimulate labor activity.