An unusual Case Report of Papillary Thyroid Carcinoma with Columnar Cell Variant Diagnosed by FNAC

Background: The columnar cell variant of papillary carcinoma of thyroid are uncommon variant and regarded as more aggressive form as compared to more common classic papillary and follicular subtypes. Case Report: A 30 year male presents with midline nodular swelling measured 2.5×2.5 cm, since one year. On examination swelling was firm, moved with deglutition and non-tender. The aspirate are hypercellular showing large fragments of cells showing nuclear overlapping with oval enlarged nucleus with fine chromatin, grooving ing and inclusions are seen. Clusters of cells showing nuclear stratification with nuclear hyperchromasia. Based on these finding diagnosis was malignant neoplastic lesion probably papillary thyroid carcinoma was made with differential diagnosis of medullary carcinoma of thyroid. Subsequent excision was done showing a tumour with papillary architecture with nuclear feature of papillary thyroid carcinoma also identified area showing follicles with marked nuclear stratification and hyperchromatic nuclei was seen. Conclusion: Nuclear overlapping, oval enlarged nucleus, grooving and nuclear stratification show feature of papillary carcinoma of thyroid columnar variant.