IMPACT OF INCREASED PROLACTIN LEVELS ON SEMINAL FLUID PARAMETERS AND MALE INFERTILITY IN WHITE NILE STATE IN SUDAN

Background: Male infertility is a global health issue with diverse etiologies and pathogenesis, this study investigates the impact of Prolactin levels on seminal fluid parameters in infertile men, to develop effective treatment strategies for male infertility. Subjects and Methods: The study recruited 200 participants, including 100 infertile males and 100 healthy fertile males, from the infertility center of Kosti, Rabak Teaching Hospitals in White Nile State, Sudan. Blood samples were collected from each participant, and the levels of prolactin were measured, semen analysis was also performed to assess sperm count, motility, and morphology. Results: The results showed that infertile males had significantly higher levels of prolactin, (18±1.42 ng/ml) compared to the healthy controls (10.4±2.95 ng/ml), p<0.001. Pearson's correlation analysis revealed a significant negative correlation between prolactin levels and sperm count, motility, and morphology. Conclusion: The findings suggest that alterations in prolactin levels may contribute to male infertility, and these hormonal parameters could be used as potential biomarkers for infertility assessment.