Formulation And Evaluation Of Emulgel For The Treatment Of Psoriasis

Psoriasis is chronic inflammatory skin disarray that may drastically affect the feature of life of an affected person. Emulgel is a drug delivery systems found effective in topical delivery. Mometasone is a medium-potency synthetic corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive properties. We used physiochemical properties of drug, and an assessment of the irrelevance to the final formulation, the chemical and physical stability of drug and compatibility of the active with potential excipients. A suitable method of analysis of drug was UV spectrophotometric. Mometasone furoate showed maximum absorption at a wavelength of 242 nm. Various formulations (F1-F8) were developed by using Carbopol 940 for local release of Mometasone furoate for the treatment of topical infections by using penetration enhancer Tween 80. Developed formulations of Mometasone furoatewere evaluated for the physiochemical parameters such as drug content, viscosity, spread ability, in vitro diffusion. Viscosity studies of various formulations revealed that formulation F4 is better compare to others. Release of drug from mometasone furoate emulgel was significantly slower, which confirmed that slight prolonged drug release rate. Incorporation of carbomer affected the release rate of the drug. By increasing the amount of carbomer, the release rate of the drug decreased, which could be related to the increased rigidity of the formulation, followed by its decreased permeability for the drug. In vitro drug release from the semisolid preparation of mometasone furoate emulgel optimized formulation F4 shows significantly improved in drug release rate as compare to marketed preparation.