IMPORTANT ROLE PLAYS OF GABA AND ITS TYPES IN ALZHEIMER'S DISEASE: A REVIEW

ABSTRACTGamma-Aminobutyric Acid (GABA) and its many receptor types have a complexfunction in Alzheimer's disease (AD), as this thorough analysis explores. An essentialinhibitory neurotransmitter, GABA, has a variety of functions in controlling brainactivity and cognitive functions. Review critically examines the existing literature onGABAergic alterations in AD, discussing how dysfunction in GABA signaling pathwaysmay contribute to disease etiology and progression. Special attention is given to thediverse GABA receptor subtypes and their potential modulatory effects in ADpathology, shedding light on the complex interplay between neurotransmission andneurodegeneration. The insights garnered from this review emphasize how crucial it isto conduct further study in order to fully understand GABAergic pathways for possibletreatment approaches. Alzheimer's disease is a progressive neurological disease that isnow incurable. Aβ-plaques and NF-tangles are its defining features. GABAis aneurotransmitter that inhibits neurons in cerebral cortex, hippocampus other parts ofbrain. An inhibitory neurotransmitter called GABA is extensively dispersedthroughout the brain's hippocampus, thalamus, basal ganglia, and core. Its primarypurpose is to suppress or lessen neuronal activity, which aids in fever, tension, anxiety, and relaxation. In pre-synaptic neurons, glutamate is converted to GABA using anenzyme named glutamate decarboxylase and vitamin B6.