To Evaluate the Efficacy and Safety Profile of Antidepressant Drugs used in Cases of Depression: A Prospective Cohort Study

Introduction: Depression, a worldwide health issue, imposes significant disability and socioeconomic consequences on individuals. India is grappling with the consequences of depression among a large portion of its population. Impacts vary from persistent pain to heart-related issues, affecting people of all ages. Depression affects over 280 million people worldwide and is a major contributor to disability, highlighting the need for successful treatment approaches. Although antidepressants are used frequently for the treatment of this disorder, there has been recent controversy about the efficacy and safety of these medications in this population. Materials and Methodology: In present study, 50 participants meeting inclusion criteria were observed over a period of two months at Parul Sevashram Hospital, Vadodara. Consent was obtained after being informed, and information regarding the patient such as demographics and treatment details were gathered. An analysis was conducted on the prescription patterns, effectiveness, and side effect of anti-depressants. Result: Prevalence of depression among males and females in the 18-80 years of age group was same. Escitalopram was the main SSRI, demonstrating excellent effectiveness and safety. Amitriptyline was popular in the category of TCAs, while venlafaxine and duloxetine were prominent choices in the SNRIs category. Clonazepam was commonly prescribed along with antidepressants. Conclusion: This research highlights the equal distribution of depression among genders and how common it is in young adults. Escitalopram was identified as the favoured SSRI, showing effectiveness and safety. Amitriptyline, venlafaxine, and duloxetine stood out as noteworthy within the category of TCAs and SNRIs. Clonazepam was the most commonly prescribed benzodiazepine along with other medications. These results highlight the significance of individualized treatment for depression, considering the effectiveness and safety of medications.