STATE OF HEPATOCYTE BIOMEMBRANES IN LIVER PATHOLOGY

In addition to the four - electron reduction of O2, processes leading to the formation of superoxide anions and hydrogen peroxides are also possible in biological systems. When exposed to superoxides and peroxides, more toxic hydroxyl radicals are formed. They are one of the most probable activators of lipid peroxidation of polyunsaturated fatty acids of phospholipids (LPO) with the formation of alkyl radicals (R), which promotes the free radical oxidation of lipids. It occurs under the influence of various agents, which include CCl4 and heliotrin. These agents penetrate the cells well, where they metabolize while forming trichloromethyl, chlorines and pyrroles, which enhance LPO.