Comparison of Evaluating Anti-Shivering effect of Magnesium Sulphate and Ondansetron during Spinal Anaesthesia

Background: Spinal anaesthesia interferes with the body’s ability to regulate temperature; sudden vasodilation caused by sympathetic blockade alters temperature perception, leading to a sensation of cold, this temperature decrease trigger shivering as a compensatory mechanism to maintain homeostasis. Aim of the Work: To evaluate the effectiveness of ondansetron and magnesium sulphate as pharmacological interventions in preventing shivering associated with spinal anaesthesia in perioperative settings in Amaltas Institute of Medical Sciences Dewas. Patients and Methods: A Single Centre, Hospital, Inpatient-based, Prospective Observational Study conducted on 90 ASA grade I and II patients, posted for surgeries undergoing spinal anesthesia in Amaltas Institute of Medical Science, Dewas, following approval from the Ethics Committee of the Amaltas Institute of Medical Science, Dewas. Results: Ondansetron was significantly more effective than Magnesium Sulphate in preventing shivering during spinal anesthesia as 88.9% of patients receiving Ondansetron experienced no shivering, whereas only 62.2% of patients receiving Magnesium Sulphate had no shivering. Only 4.44% of patients in the Ondansetron group required rescue medication (Tramadol), compared to 17.8% in Magnesium Sulphate group. The mean time to rescue medication was significantly longer for Ondansetron (59.7 minutes) compared to Magnesium Sulphate (45.4 minutes). Both Ondansetron and Magnesium Sulphate were well-tolerated with minimal side effects. Conclusion: Ondansetron is an effective drug in the prevention of shivering in patients undergoing spinal anesthesia.